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. 2024 Nov 27;13(11):6255–6272. doi: 10.21037/tcr-24-1403

Figure 9.

Figure 9

AIM2-related canonical inflammasomes signaling pathway. A significant positive correlation was found between AIM2 and key inflammasome components, including CASP1, PYCARD, IL-18, IL-10, IL-1B, and NLRP3 (A). The association between key inflammasome components and FLT3 mutation status in AML (B). The expression of key inflammasome components was also investigated in TCGA and GTEx databases (C). *, P<0.05; **, P<0.01; ***, P<0.001. TPM, transcripts per million; AIM2, absent in melanoma 2; AML, acute myeloid leukemia; FLT3, FMS-like tyrosine kinase 3; TCGA, The Cancer Genome Atlas; GTEx, Genotype-Tissue Expression; CASP1, caspase 1; PYCARD, a N-terminal PYRIN-PAAD-DAPIN domain) and a C-terminal caspase-recruitment domain containing; IL-18, interleukin-18; IL-10, interleukin-10; IL-1B, interleukin-1β; NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3.