Table 1. Patients’ baseline characteristics.
Variables | t-MNs (−) | t-MNs (+) | Total |
---|---|---|---|
Patient number | 48 | 4 | 52 |
Age at OC or PPC (years) | 57 [37–77] | 45 [42–53] | 56 [37–77] |
Presence of germline BRCA 1/2 (+) mutation | 28 (58.3) | 4 (100.0) | 32 (61.5) |
Diagnosed other cancer | 7 (14.6) | 2 (50.0) | 9 (17.3) |
Cancer type | |||
OC | 44 (91.7) | 4 (100.0) | 48 (92.3) |
PPC | 4 (8.3) | 0 (0.0) | 4 (7.7) |
OC or PPC stage | 45 | 4 | 49 |
II | 1 (2.2) | 0 (0.0) | 1 (2.0) |
III | 37 (82.2) | 1 (25.0) | 38 (77.6) |
IV | 7 (15.5) | 3 (75.0) | 10 (20.4) |
Median number of chemotherapy agent | 4 | 7 | 5 |
Radiotherapy | 10 (20.8) | 4 (100.0) | 14 (26.9) |
G-CSF application | 26 (54.1) | 4 (100.0) | 30 (57.7) |
Type of PARPi | |||
Olaparib | 21 (43.8) | 4 (100.0) | 25 (48.1) |
Niraparib | 27 (56.3) | 0 (0.0) | 27 (51.9) |
Reasons for quitting PARPi | |||
Progression of cancer | 24 (50.0) | 4 (100.0) | 28 (53.8) |
Side effect | 2 (4.2) | 0 (0.0) | 2 (3.8) |
Ends after maintenance therapy period | 6 (12.5) | 0 (0.0) | 6 (11.5) |
Other cause | 6 (12.5) | 0 (0.0) | 6 (11.5) |
Ongoing | 10 (20.8) | 0 (0.0) | 10 (19.2) |
PARPi usage period (months) | 13.4 [0.2–68.2] | 16.3 [6.2–48.8] | 14.2 [0.2–68.2] |
OS from OC diagnosis (years) | 4.8 [1.2–20.9] | 13.4 [8.1–17.6] | 5.2 [1.2–20.9] |
Data are presented as number, median [range], or n (%), unless otherwise stated. t-MNs, therapy-related myeloid neoplasms; OC, ovarian cancer; PPC, primary peritoneal cancer; BRCA, breast cancer gene; G-CSF, granulocyte colony stimulating factor; PARPi, poly(ADP-ribose) polymerase inhibitor; OS, overall survival.