Skip to main content
. 2024 Nov 12;13(11):6018–6027. doi: 10.21037/tcr-24-1131

Table 1. Patients’ baseline characteristics.

Variables t-MNs (−) t-MNs (+) Total
Patient number 48 4 52
Age at OC or PPC (years) 57 [37–77] 45 [42–53] 56 [37–77]
Presence of germline BRCA 1/2 (+) mutation 28 (58.3) 4 (100.0) 32 (61.5)
Diagnosed other cancer 7 (14.6) 2 (50.0) 9 (17.3)
Cancer type
   OC 44 (91.7) 4 (100.0) 48 (92.3)
   PPC 4 (8.3) 0 (0.0) 4 (7.7)
OC or PPC stage 45 4 49
   II 1 (2.2) 0 (0.0) 1 (2.0)
   III 37 (82.2) 1 (25.0) 38 (77.6)
   IV 7 (15.5) 3 (75.0) 10 (20.4)
Median number of chemotherapy agent 4 7 5
Radiotherapy 10 (20.8) 4 (100.0) 14 (26.9)
G-CSF application 26 (54.1) 4 (100.0) 30 (57.7)
Type of PARPi
   Olaparib 21 (43.8) 4 (100.0) 25 (48.1)
   Niraparib 27 (56.3) 0 (0.0) 27 (51.9)
Reasons for quitting PARPi
   Progression of cancer 24 (50.0) 4 (100.0) 28 (53.8)
   Side effect 2 (4.2) 0 (0.0) 2 (3.8)
   Ends after maintenance therapy period 6 (12.5) 0 (0.0) 6 (11.5)
   Other cause 6 (12.5) 0 (0.0) 6 (11.5)
   Ongoing 10 (20.8) 0 (0.0) 10 (19.2)
PARPi usage period (months) 13.4 [0.2–68.2] 16.3 [6.2–48.8] 14.2 [0.2–68.2]
OS from OC diagnosis (years) 4.8 [1.2–20.9] 13.4 [8.1–17.6] 5.2 [1.2–20.9]

Data are presented as number, median [range], or n (%), unless otherwise stated. t-MNs, therapy-related myeloid neoplasms; OC, ovarian cancer; PPC, primary peritoneal cancer; BRCA, breast cancer gene; G-CSF, granulocyte colony stimulating factor; PARPi, poly(ADP-ribose) polymerase inhibitor; OS, overall survival.