Table 1. Demographic information of the participants from the ADNI, AIBL, EDSD, and OASIS databases.
| Cohort | Group | Age (years) | Sex (M/F) | MMSE |
|---|---|---|---|---|
| ADNI (N=1,655) | NC (n=603) | 73.46±6.16 | 277/326 | 29.08±1.10 |
| MCI (n=770) | 72.98±7.68 | 447/323 | 27.56±1.81 | |
| AD (n=282) | 74.91±7.69 | 151/131 | 23.18±2.13 | |
| P value | <0.001 | <0.001 | <0.001 | |
| AIBL (N=557) | NC (n=478) | 73.10±6.10 | 203/275 | 28.70±1.24 |
| AD (n=79) | 74.16±7.84 | 33/46 | 20.41±5.49 | |
| P value | 0.172 | 0.908 | <0.001 | |
| EDSD (N=388) | NC (n=230) | 68.76±6.14 | 108/122 | 28.58±2.97 |
| AD (n=158) | 75.54±8.10 | 66/92 | 20.89±5.12 | |
| P value | <0.001 | 0.072 | <0.001 | |
| OASIS (N=783) | NC (n=594) | 67.07±8.70 | 240/354 | 29.06±1.54 |
| AD (n=189) | 75.04±7.70 | 95/94 | 24.47±4.14 | |
| P value | <0.001 | <0.05 | <0.001 |
Significant difference at P<0.001. MMSE and age are expressed as the mean ± standard deviation. ADNI, The Alzheimer’s Disease Neuroimaging Initiative; AIBL, Australian Imaging Biomarkers and Lifestyle; EDSD, The European DTI Study on Dementia database; OASIS, The Open Access Series of Imaging Studies; AD, Alzheimer’s disease; MCI, mild cognitive impairment; NC, normal control; MMSE, Mini-Mental State Examination; DTI, diffusion tensor imaging; M/F, male/female.