Table 6. Ablation of single-spatial information and multispatial information based on AD vs. NC classification task in the ADNI cohort.

Model input	Interactive mechanism	ACC (%)	SEN (%)	SPE (%)	AUC (%)
radMBN		89.1	76.5	95.0	94.9
GMV		91.8	87.5	93.8	95.5
radMBN + GMV	×	92.1	86.1	95.0	95.2
radMBN + GMV + topology	×	92.2	86.5	94.8	95.3
radMBN + GMV + topology (proposed MSRNet)	√	92.8	88.2	95.0	95.6

The column titled “Interactive mechanism” indicates whether the image information is integrated into important brain regions, with “√” denoting yes and “×” denoting no. AD, Alzheimer’s disease; NC, normal control; ADNI, Alzheimer’s Disease Neuroimaging Initiative database; ACC, accuracy; SEN, sensitivity; SPE, specificity; AUC, area under the curve; radMBN, radiomics-based morphology brain network; GMV, gray-matter volume.