Table 5. Univariable and multivariable logistic regression analysis of risk factors for csPCa in the training cohort.
| Variables | Univariable analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | ||
| Age (years) | 1.075 (1.039–1.114) | <0.001* | 1.052 (1.002–1.108) | 0.047* | |
| tPSA (ng/mL) | 1.024 (1.010–1.045) | 0.006* | 1.001 (0.990–1.030) | 0.908 | |
| fPSA (ng/mL) | 1.217 (1.077–1.443) | 0.010* | 1.094 (0.940–1.416) | 0.456 | |
| f/t PSA | 0.158 (0.009–2.862) | 0.207 | |||
| ADC (×10−6 mm2/s) | 0.993 (0.991–0.995) | <0.001* | 0.997 (0.994–0.999) | 0.016* | |
| T1 (msec) | 0.995 (0.9923–0.997) | <0.001* | 1.002 (0.998–1.006) | 0.278 | |
| T2 (msec) | 0.920 (0.892–0.946) | <0.001* | 0.956 (0.904–1.005) | 0.092 | |
| PD (pu) | 0.802 (0.711–0.895) | <0.001* | 0.898 (0.747–1.0717) | 0.237 | |
| PI-RADS | |||||
| PI-RADS 3 | – | – | |||
| PI-RADS 4 | 8.932 (3.985–21.250) | <0.001* | 6.469 (2.518–17.659) | <0.001* | |
| PI-RADS 5 | 30.870 (13.799–74.732) | <0.001* | 10.179 (3.861–28.673) | <0.001* | |
*, statistically significant. csPCa, clinically significant prostate cancer; CI, confidence interval; tPSA, total prostate-specific antigen; fPSA, free prostate-specific antigen; f/t PSA, free/total prostate-specific antigen ratio; ADC, apparent diffusion coefficient; T1, longitudinal relaxation time; T2, transverse relaxation time; PD, proton density; PI-RADS, Prostate Imaging-Reporting and Data System.