Table 1. Characteristics of the training cohort and the external test cohort.
| Characteristics | Overall (n=493) | Training (n=426) | Internal validation (n=67) | P value | External test (n=46) |
|---|---|---|---|---|---|
| Age (years) | 59 [47–68] | 60 [48–69] | 56 [44–65] | 0.054a | 55 [47–62] |
| Sex | 0.289b | ||||
| Female | 199 (40.4) | 168 (39.4) | 31 (46.3) | 22 (47.8) | |
| Male | 294 (59.6) | 258 (60.6) | 36 (53.7) | 24 (52.2) | |
| Grade | 0.321b | ||||
| 2 | 54 (11.0) | 50 (11.7) | 4 (6.0) | 19 (41.3) | |
| 3 | 43 (8.7) | 38 (8.9) | 5 (7.5) | 6 (13.0) | |
| 4 | 396 (80.3) | 338 (79.3) | 58 (86.6) | 21 ( (45.7) | |
| IDH | 0.847b | ||||
| Wild-type | 393 (79.7) | 339 (79.6) | 54 (80.6) | 23 (50.0) | |
| Mutant | 100 (20.3) | 87 (20.4) | 13 (19.4) | 23 (50.0) | |
| MGMT | 0.292b | ||||
| Unmethylated | 117 (28.2) | 104 (29.1) | 13 (22.4) | 0 | |
| Methylated | 298 (71.8) | 253 (70.89) | 45 (77.6) | 0 |
Patients’ age is reported as median [interquartile range]. Nominal variables are reported as n (%). a, Mann-Whitney-U test; b, chi-squared test. IDH, isocitrate dehydrogenase; MGMT, oxygen 6-methylguanine-DNA methyltransferase.