Table 3. Performance of multiparametric MRI radiomics models to predict IDH mutation status.

Cohort	Modality	AUC (95% CI)	ACC	F1 score	SENS	SPEC	PPV	NPV	MCC
Internal validation	Structural MRI	0.946 (0.895–0.997)	0.866	0.710	0.846	0.870	0.611	0.959	0.639
	ADC	0.790 (0.666–0.914)	0.701	0.524	0.846	0.667	0.379	0.947	0.409
	SWI	0.862 (0.762–0.962)	0.836	0.593	0.615	0.889	0.571	0.906	0.490
	Structural MRI + ADC	0.936 (0.876–0.995)	0.866	0.571	0.462	0.963	0.750	0.881	0.518
	Structural MRI + SWI	0.944 (0.891–0.998)	0.896	0.696	0.615	0.963	0.800	0.912	0.642
	Structural MRI + ADC + SWI	0.953 (0.904–1.000)	0.851	0.667	0.769	0.870	0.588	0.940	0.581
	1-year radiologist	–	0.776	0.634	1.000	0.464	0.722	1.000	0.579
	5-year radiologist	–	0.791	0.749	0.815	0.692	0.917	0.474	0.445
External test	Structural MRI	0.917 (0.801–1.000)	0.853	0.857	0.833	0.875	0.882	0.824	0.707
	ADC	0.701 (0.515–0.888)	0.559	0.694	0.944	0.125	0.548	0.667	0.122
	SWI	0.795 (0.637–0.954)	0.618	0.435	0.278	1.000	1.000	0.552	0.391
	Structural MRI + ADC	0.882 (0.755–1.000)	0.618	0.480	0.333	0.938	0.857	0.556	0.334
	Structural MRI + SWI	0.872 (0.733–1.000)	0.588	0.417	0.278	0.938	0.833	0.536	0.282
	Structural MRI + ADC + SWI	0.887 (0.755–1.000)	0.794	0.800	0.778	0.813	0.824	0.765	0.589
	1-year radiologist	–	0.761	0.760	0.739	0.783	0.773	0.750	0.522
	5-year radiologist	–	0.783	0.780	0.739	0.826	0.810	0.760	0.567

IDH, isocitrate dehydrogenase; AUC, area under the curve; CI, confidence interval; ACC, accuracy; SENS, sensitivity; SPEC, specificity; PPV, positive predictive value; NPV, negative predictive value; MCC, Matthew’s correlation coefficient; ADC, apparent diffusion coefficient; SWI, susceptibility-weighted imaging; MRI, magnetic resonance imaging.