Figure 2.

Linkage disequilibrium (LD) and haplotype analysis of the UMOD-PDILT locus. (a) LD map of the UMOD-PDILT locus based on 1000 Genomes Project summary data for African (n = 661) and European (n = 502) populations. D’ values are indicated, and the 3 SNPs of interest highlighted on the graph with their LD statistics (D’ and r²) shown below. Graph generated using Haploview 4.2. (b) LD estimates (D’ and r²) for 3 SNPs of interest in Whites (n = 535) and Blacks (n = 543) from the African-PREDICT cohort. (c) Haplotype frequency estimates in Whites and Blacks from the African-PREDICT cohort. Only the 3 most common haplotypes are shown. The grey star shows a recombination event between rs4293393 and rs12917707 that is frequent in blacks and virtually absent in whites. MAF, minor allele frequencies.