Figure 5.

Evolution of liver function and blood routine test in response to pegylated interferon-α-2b over 48 weeks in treatment-naïve group and nucleos(t)ide analogs (NAs)-experienced group. Changes of (A) alanine aminotransferase (ALT) level, (B) aspartate aminotransferase (AST) level, (C) albumin level, (D) white blood cells (WBC) count, (E) neutrophils count, (F) platelets count, (G) hemoglobin (HGB) level at different observational time points in two groups. The black line indicates treatment-naïve group, while the red line indicates NAs-experienced group. The points indicate median or mean, while the bars indicate interquartile range or standard deviation. Statistical analyses were performed using Kriskal-Wallis H test followed by Dunn’s multiple comparison test or one-way analysis of variance followed by Tukey test. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 compared with baseline. ^&p < 0.05 compared with NAs-experienced group in the same observational time point.