TABLE 1.
Characteristics of the 5513 included patients with locally resected T1 CRCs from the Palga cohort.
| Total | LVI absent | LVI present | p Value | |
|---|---|---|---|---|
| n = 5513 | n = 4499 | n = 1014 | ||
| Age, in years, median (IQR) | 67 (12) | 67 (12) | 67 (12) | 0.212 |
| Gender, n (%) | 0.477 | |||
| Male | 3453 (62.6) | 2808 (62.5) | 645 (63.6) | |
| Female | 2060 (37.4) | 1691 (37.5) | 369 (36.4) | |
| Type of laboratory, n (%) | <0.001 | |||
| Non‐academic | 4908 (89.0) | 4078 (90.6) | 830 (81.9) | |
| Academic | 605 (11.0) | 421 (9.4) | 184 (18.1) | |
| Year of diagnosis, n (%) | <0.001 | |||
| 2015 | 1074 (19.5) | 910 (20.2) | 164 (16.2) | |
| 2016 | 1206 (21.9) | 1004 (22.3) | 202 (19.9) | |
| 2017 | 1102 (20.0) | 905 (20.1) | 197 (19.4) | |
| 2018 | 1177 (21.3) | 942 (20.9) | 235 (23.2) | |
| 2019 | 954 (17.3) | 738 (16.5) | 216 (21.3) | |
| Screen‐detected, n (%) | 0.104 | |||
| No | 2505 (45.4) | 2021 (44.9) | 484 (47.7) | |
| Yes | 3008 (54.6) | 2478 (55.1) | 530 (52.3) | |
| Location, n (%) | 0.825 | |||
| Colon | 3513 (64.2) | 2863 (64.2) | 650 (64.5) | |
| Rectum | 1955 (35.8) | 1598 (35.8) | 357 (35.5) | |
| Missing | 45 | 38 | 7 | |
| Diameter polyp, in mm, median (IQR) | 15 (10) | 15 (10) | 16 (12) | <0.05 |
| Differentiation, n (%) | <0.001 | |||
| Low‐grade | 5246 (98.3) | 4304 (98.8) | 942 (95.9) | |
| High‐grade | 91 (1.7) | 51 (1.2) | 40 (4.1) | |
| Missing | 176 | 144 | 32 | |
| Invasion depth, n (%) | <0.001 | |||
| sm1/Haggitt 1–2/<1 mm | 2413 (48.3) | 2029 (50.0) | 384 (50.0) | |
| sm2/Haggitt 3/1–2 mm | 1135 (22.7) | 859 (21.2) | 276 (29.5) | |
| sm3/Haggitt 4/>2 mm | 541 (10.8) | 416 (10.2) | 125 (13.3) | |
| Could not be assessed | 906 (18.1) | 754 (18.6) | 152 (16.2) | |
| Missing | 518 | 441 | 77 | |
| Resection margin, n (%) | 0.555 | |||
| R0 | 4185 (76.0) | 3408 (75.8) | 777 (76.7) | |
| R1 | 782 (14.2) | 636 (14.2) | 146 (14.4) | |
| Rx | 540 (9.8) | 450 (10.0) | 90 (8.9) | |
| Missing | 6 | 5 | 1 | |
| Treatment strategy, n (%) | <0.001 | |||
| Local resection only | 4176 (75.7) | 3750 (83.4) | 426 (42.0) | |
| Completion surgery | 1337 (24.3) | 749 (16.6) | 588 (58.0) |
Note: Significance for italic value is ‘These data were missing in the original pathology report’.
Abbreviations: CRC, colorectal cancer; IQR, inter quartile range; LVI, lymphovascular invasion; R0, free resection margin; R1, positive resection margin; Rx, unassessable resection margin.