TABLE 2.
Multivariable logistic regression analysis for the association between LVI detection practice and surgical resection rate or LNM‐negative surgeries in a nationwide Palga cohort of 5513 locally resected T1 CRCs.
| Multivariable OR (95% CI) | |
|---|---|
| Surgical resection rate | |
| LVI detection practice a | |
| Low detectors | Ref |
| Average detectors | 1.05 (0.89–1.25) |
| High detectors | 1.87 (1.52–2.31) |
| Differentiation | |
| Low‐grade | Ref |
| High‐grade | 5.57 (3.52–8.90) |
| Resection margin | |
| R0 | Ref |
| R1 | 6.66 (5.57–7.95) |
| Rx | 3.01 (2.44–3.70) |
| Age | 0.96 (0.95–0.97) |
| Tumour location | |
| Colon | Ref |
| Rectum | 0.46 (0.39–0.53) |
| Year of diagnosis | |
| 2015 | Ref |
| 2016 | 0.92 (0.75–1.13) |
| 2017 | 0.82 (0.66–1.02) |
| 2018 | 0.81 (0.66–1.01) |
| 2019 | 0.69 (0.55–0.87) |
| LNM‐negative surgeries | |
| LVI detection practice a | |
| Low detectors | Ref |
| Average detectors | 1.00 (0.84–1.20) |
| High detectors | 1.73 (1.39–2.15) |
| Differentiation | |
| Low‐grade | Ref |
| High‐grade | 3.91 (2.50–6.13) |
| Resection margin | |
| R0 | Ref |
| R1 | 5.39 (4.50–6.44) |
| Rx | 2.92 (2.35–3.60) |
| Age | 0.97 (0.96–0.98) |
| Tumour location | |
| Colon | Ref |
| Rectum | 0.47 (0.40–0.55) |
| Year of diagnosis | |
| 2015 | Ref |
| 2016 | 0.90 (0.73–1.11) |
| 2017 | 0.76 (0.60–0.95) |
| 2018 | 0.77 (0.62–0.97) |
| 2019 | 0.64 (0.50–0.81) |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; LNM, lymph node metastasis; LVI, lymphovascular invasion; OR, odds ratio; Ref, reference category; R0, microscopically free resection margin; R1, microscopically positive resection margin; Rx, resection margin could not be assessed.
Low detectors: proportion of LVI positive T1 CRCs is lower than Q1 of the national median proportion, average detectors: proportion of LVI positive T1 CRCs is between Q1 and Q3 of the national median proportion, high detectors: proportion of LVI positive T1 CRCs is higher than Q3 of the national median proportion.