TABLE 3.
Multivariable Cox regression analysis for the association between LVI detection practice and cancer recurrences in the T1 CRC Working Group cohort of 847 locally resected T1 CRCs.
| Multivariable HR (95% CI) | |
|---|---|
| LVI detection practice a | |
| Low detectors | Ref |
| Average detectors | 1.36 (0.54–3.45) |
| High detectors | 2.23 (0.95–5.23) |
| Differentiation | |
| Low‐grade | Ref |
| High‐grade | 0.00 (0.00 ‐ ∞) |
| Resection margin | |
| R0 | Ref |
| R1 | 1.03 (0.30–3.58) |
| Rx | 1.78 (0.77–4.12) |
| Age | 1.04 (0.99–1.09) |
| Location | |
| Colon | Ref |
| Rectum | 3.91 (1.83–8.34) |
| Year diagnosis | |
| 2014 | Ref |
| 2015 | 1.41 (0.47–4.21) |
| 2016 | 2.00 (0.70–5.73) |
| 2017 | 1.64 (0.51–5.25) |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; LVI, lymphovascular invasion; Ref, reference category; R0, microscopically free resection margin; R1, microscopically positive resection margin; Rx, resection margin could not be assessed.
Low detectors: proportion of LVI positive T1 CRCs is lower than Q1 of the national median proportion, average detectors: proportion of LVI positive T1 CRCs is between Q1 and Q3 of the national median percentage, high detectors: proportion of LVI positive T1 CRCs is higher than Q3 of the national median proportion.