TABLE 2.
Risk of incident cancer among individuals with histologically defined EoE compared to general population controls.
| Cancer | EoE | General population reference individuals | |
|---|---|---|---|
| Any cancer | N | 1580 | 7533 |
| Event | 47 | 183 | |
| IR [95% CI] | 3.9 [3.0–5.1] | 3.2 [2.8–3.7] | |
| IRD [95% CI] | 0 [−1.6 to 1.6] | −0.7 [−1.9 to 0.5] | |
| HR [95% CI] | NA | 1.11 [0.81–1.53] | |
| aHR [95% CI] | NA | 1.11 [0.80–1.53] | |
| Esophageal cancer | Event | 2 | 1 |
| IR [95% CI] | 0.2 [0.1–0.5] | 0.0 [0.0–0.1] | |
| IRD [95% CI] | 0 [−0.3 to 0.3] | −0.1 [−0.4 to 0.1] | |
| HR [95% CI] | NA | 18.35 [1.66–202.97] | |
| aHR [95% CI] | NA | 25.20 [2.28–278.80] | |
| Gastrointestinal cancer a (not esophageal) | Event | 11 | 24 |
| IR [95% CI] | 0.9 [0.5–1.5] | 0.4 [0.3–0.6] | |
| IRD [95% CI] | 0 [−0.8 to 0.8] | −0.5 [−1.1 to 0.1] | |
| HR [95% CI] | NA | 2.09 [1.02–4.28] | |
| aHR [95% CI] | NA | 2.03 [0.99–4.18] | |
| Skin cancer | Event | 10 | 30 |
| IR [95% CI] | 0.8 [0.5–1.4] | 0.5 [0.4–0.7] | |
| IRD [95% CI] | 0 [−0.7 to 0.7] | −0.3 [−0.9 to 0.2] | |
| HR [95% CI] | NA | 1.37 [0.67–2.82] | |
| aHR [95% CI] | NA | 1.31 [0.63–2.70] | |
| Lung cancer | Event | 0 | 7 |
| IR [95% CI] | 0 | 0.1 [0.1–0.2] | |
| IRD [95% CI] | 0 | 0.1 [0–0.2] | |
| HR [95% CI] | NA | NA | |
| aHR [95% CI] | NA | NA | |
| Breast cancer | Event | 4 | 10 |
| IR [95% CI] | 0.3 [0.1–0.7] | 0.2 [0.1–0.3] | |
| IRD [95% CI] | 0 [−0.5 to 0.5] | −0.2 [−0.5 to 0.2] | |
| HR [95% CI] | NA | 1.68 [0.53–5.35] | |
| aHR [95% CI] | 1.67 [0.52–5.33] | ||
| Hematologic cancers b | Event | 0 | 13 |
| IR [95% CI] | 0.0 [0.0–0.0] | 0.2 [0.1–0.4] | |
| IRD [95% CI] | NA | 0.2 [0.1–0.3] | |
| HR [95% CI] | NA | NA | |
| aHR [95% CI] | NA | NA |
Note: NA values could not be calculated due to insufficient data.
Abbreviations: aHR, adjusted HR for age at EoE, sex, calendar year, county where biopsy obtained, education and immune‐mediated diagnosis at baseline (EoE diagnosis date or matching date in reference individuals, Table S2); HR, hazard ratio adjusted for age, sex, calendar year, county, and education; IR, incidence rate per 1000 person‐years; IRD, incidence rate difference per 1000 person‐years.
Any GI cancer including liver cancer but excludes esophageal (see Table S1 for ICD list of codes: gastric, small bowel, colon, liver, biliary, pancreas, peritoneum, unspecified digestive organ).
Extrahepatic hematological cancer.