TABLE 5.

Risk of incident cancer among individuals with histologically defined EoE compared to full siblings.

Cancer		EoE	Siblings
Any cancer	N	1194	1997
	Event	27	55
	IR [95% CI]	3.0 [2.0–4.2]	3.6 [2.8–4.6]
	IRD [95% CI]	0 [−1.6 to 1.6]	0.6 [−0.8 to 2.1]
	HR [95% CI]		0.87 [0.54–1.41]
	aHR [95% CI]		1.10 [0.65–1.85]
Esophageal cancer	Event	1	0
	IR [95% CI]	0.1 [0.0–0.4]	0.0 [0.0–0.0]
	IRD [95% CI]	0 [−0.3 to 0.3]	−0.1 [−0.3 to 0.1]
	HR [95% CI]	1	NA
	aHR [95% CI]	1	NA
Gastrointestinal cancer a (not esophageal)	Event	6	4
	IR [95% CI]	0.7 [0.3–1.3]	0.3 [0.1–0.6]
	IRD [95% CI]	0 [−0.7 to 0.7]	−0.4 [−1 to 0.2]
	HR [95% CI]	1	2.86 [0.78–10.50]
	aHR [95% CI]	1	NA
Skin cancer	Event	6	10
	IR [95% CI]	0.7 [0.3–1.3]	0.6 [0.4–1.1]
	IRD [95% CI]	0 [−0.7 to 0.7]	0 [−0.7 to 0.7]
	HR [95% CI]	1	1.16 [0.40–3.37]
	aHR [95% CI]	1	0.92 [0.27–3.07]
Breast cancer	Event	1	9
	IR [95% CI]	0.1 [0.0–0.4]	0.6 [0.3–1.0]
	IRD [95% CI]	0 [−0.3 to 0.3]	0.5 [0–0.9]
	HR [95% CI]	1
	aHR [95% CI]	1	0.52 [0.04–6.30]

Note: NA values could not be calculated due to insufficient data#Extrahepatic hematological cancer. Please note that hazard ratios for lung cancer and extrahepatic hematological cancer were not calculated due to insufficient statistical power seen already in the general population comparison (see Table 2).

Abbreviations: aHR, adjusted HR for age at EoE, sex, calendar year, county where biopsy obtained, education and immune‐mediated diagnosis at baseline (EoE diagnosis date or matching date in reference individuals, Table S2); HR, hazard ratio adjusted for age, sex, calendar year, county, and education; IR, incidence rate; IRD, incidence rate difference.

^a Any GI cancer including liver cancer but excludes esophageal (see Table S1 for ICD list of codes: gastric, small bowel, colon, liver, biliary, pancreas, peritoneum, unspecified digestive organ).