Table 2.
Estimates of random effects and shrinkage for the model.
| single run | nKa1 | nKa2 | nF1 | nTlag | nFrapid | nV1 | nV2 | nV3 | nCl | nCl2 | nCl3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Omega | |||||||||||
| nKa1 | 0.080095 | ||||||||||
| nKa2 | 0.103949 | 0.19011 | |||||||||
| nF1 | −0.095537 | −0.138489 | 0.331033 | ||||||||
| nTlag | −0.02741 | −0.02635 | 0.068231 | 0.040549 | |||||||
| nFrapid | 0.02069 | 0.038294 | −0.05192 | −0.01144 | 0.015948 | ||||||
| nV1 | NA | NA | NA | NA | NA | 0.527444 | |||||
| nV2 | NA | NA | NA | NA | NA | −0.07716 | 0.031032 | ||||
| nV3 | NA | NA | NA | NA | NA | −0.07185 | 0.02222 | 0.107616 | |||
| nCl | NA | NA | NA | NA | NA | 0.055107 | −0.00525 | 0.018945 | 0.039763 | ||
| nCl2 | NA | NA | NA | NA | NA | 0.010349 | 0.013185 | 0.041094 | 0.016754 | 0.047794 | |
| nCl3 | NA | NA | NA | NA | NA | 0.080094 | 0.009562 | 0.055244 | 0.045213 | 0.029476 | 0.19877 |
| BSV% | 28.87 | 45.76 | 62.64 | 20.34 | 12.68 | 83.34 | 17.75 | 33.71 | 20.14 | 22.13 | 46.89 |
| Correlation | |||||||||||
| nKa1 | 1 | ||||||||||
| nKa2 | 0.842394 | 1 | |||||||||
| nF1 | −0.58672 | −0.55205 | 1 | ||||||||
| nTlag | −0.48093 | −0.30017 | 0.588923 | 1 | |||||||
| nFrapid | 0.578894 | 0.695451 | −0.7145 | −0.44997 | 1 | ||||||
| nV1 | NA | NA | NA | NA | NA | 1 | |||||
| nV2 | NA | NA | NA | NA | NA | −0.60313 | 1 | ||||
| nV3 | NA | NA | NA | NA | NA | −0.30158 | 0.384502 | 1 | |||
| nCl | NA | NA | NA | NA | NA | 0.380524 | −0.14941 | 0.289613 | 1 | ||
| nCl2 | NA | NA | NA | NA | NA | 0.06518 | 0.34238 | 0.573001 | 0.384322 | 1 | |
| nCl3 | NA | NA | NA | NA | NA | 0.247366 | 0.121745 | 0.377718 | 0.508565 | 0.302416 | 1 |
| Shrinkage | 16.7% | 20.0% | 25.6% | 43.9% | 18.2% | 12.8% | 26.0% | 44.6% | 15.7% | 41.1% | 21.4% |
Distribution and bioavailability parameters are set as a full variance/covariance matrix (absorption rates, lag time and bioavailability) as also are the elimination parameters (volumes of distribution and clearances).