Table 5.

Differences in comorbidities and risk factors among hospitalized patients for invasive pneumococcal disease in the metropolitan area of Zagreb (2010–2022) regarding their pneumoccocal vaccination status.

Comorbidities and risk factors		Pneumococcal vaccination				P value
		No		Yes
		N	%	N	%
Gender	Male	207	54.8%	7	63.6%	0.761
	Female	171	45.2%	4	36.4%
Alcoholism	No	269	71.2%	7	63.6%	0.737
	Yes	109	28.8%	4	36.4%
Tobacco smoking	No	249	66.0%	7	63.6%	1.000
	Yes	128	34.0%	4	36.4%
Hypogammaglobulinemia	No	373	98.7%	9	81.8%	0.014
	Yes	5	1.3%	2	18.2%
Congenital or acquired asplenia	No	375	99.5%	8	72.7%	<0.001
	Yes	2	0.5%	3	27.3%
HIV infection	No	376	99.5%	11	100.0%	1.000
	Yes	2	0.5%	0	0.0%
Malignant hematology diseases	No	350	92.6%	9	81.8%	0.205
	Yes	28	7.4%	2	18.2%
Organ transplant	No	368	97.4%	10	90.9%	0.274
	Yes	10	2.6%	1	9.1%
Corticosteroid therapy	No	329	87.0%	9	81.8%	0.643
	Yes	49	13.0%	2	18.2%
Chronic pulmonary disease	No	337	89.2%	11	100.0%	0.615
	Yes	41	10.8%	0	0.0%
Heart disease	No	302	79.9%	10	90.9%	0.700
	Yes	76	20.1%	1	9.1%
Cardiovascular disease	No	202	53.4%	8	72.7%	0.236
	Yes	176	46.6%	3	27.3%
Diabetes mellitus	No	304	80.4%	11	100.0%	0.134
	Yes	74	19.6%	0	0.0%
Chronic kidney disease	No	357	94.4%	11	100.0%	1.000
	Yes	21	5.6%	0	0.0%
Neurodegenerative disease	No	360	95.2%	11	100.0%	1.000
	Yes	18	4.8%	0	0.0%
Cerebrovascular diseases	No	352	93.1%	11	100.0%	1.000
	Yes	26	6.9%	0	0.0%
CNS trauma	No	364	96.3%	9	81.8%	0.070
	Yes	14	3.7%	2	18.2%
Chronic liver disease	No	330	87.3%	11	100.0%	0.373
	Yes	48	12.7%	0	0.0%
Malignant disease	No	320	84.7%	9	81.8%	0.681
	Yes	58	15.3%	2	18.2%

Bold values are those that are statistically significant.