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. 2024 Dec 17;30(12):e70145. doi: 10.1111/cns.70145

FIGURE 1.

FIGURE 1

ESK treatment attenuates weight loss and improves neurological and motor function in mice with ICH. (A) ICH was induced in C57BL/6 mice via collagenase injection into the right striatum. (B) Different groups of brain water content on Day 3 after ICH and brain injury volume measurement according to Luxol fast blue/cresyl violet (LFB/CV) staining (n = 6). (C) Representative brain sections stained with LFB/CV and hematoxylin and eosin. (D) Body weight ratio. (E) Neurological deficit score. (F) Behavioral assessments using the rotarod test, beam walking test, and grid walking test. *p < 0.05, **p < 0.01: ICH + vehicle versus sham; # p < 0.05, ## p < 0.01: ICH + ESK20 versus ICH + vehicle (n = 6). All data are mean ± SD.