TABLE 1.
Cytokine production in response to LSA-1 polypeptides in consecutive transmission seasons
| Cytokine (stimulant) | Low-transmission season
|
High-transmission season
|
||||||
|---|---|---|---|---|---|---|---|---|
| Mean (±SEM) cytokine concn (pg/ml) | n | Range | % Responders (≥10 pg of cytokine/ml) | Mean (±SEM) cytokine concn (pg/ml) | n | Range | % Responders (≥10 pg of cytokine/ml) | |
| IFN-γ (LSA N) | 122 (29) | 141 | 0–2,637 | 60 | 17.7 (7.5) | 120 | 0–636 | 19 |
| IFN-γ (LSA C) | 212 (50) | 141 | 0–3,818 | 57 | 13.5 (6) | 120 | 0–551 | 14 |
| TNF-α (LSA N) | 77 (15) | 141 | 0–1,627 | 62 | 282 (88) | 120 | 0–8,694 | 31 |
| TNF-α (LSA C) | 147 (29) | 141 | 0–2,708 | 71 | 624 (114) | 120 | 0–6,998 | 63 |
| IL-10 (LSA N) | 33 (4) | 141 | 0–464 | 61 | 88 (21) | 118 | 0–1,324 | 43 |
| IL-10 (LSA C) | 8 (1.4) | 140 | 0–109 | 24 | 33 (9.7) | 113 | 0–752 | 27 |