Table 1.
Baseline characteristics
| All patients | Patients with measured trimethoprim concentrations | |
|---|---|---|
| n = 168 | n = 52 | |
| Patient characteristics | ||
| Males (% of total) | 108 (64.3) | 33 (63.4) |
| Age (years) (mean, SD) | 58.2 ± 15.2 | 60.3 ± 11.9 |
| Weight (kg) (mean, SD) | 76.7 ± 16.2 | 80.6 ± 18.5 |
| Height (cm) (mean, SD) | 174.0 ± 10.3 | 173.8 ± 11.1 |
| BMI (kg/m2) (mean, SD) | 25.3 ± 5.0 | 26.5 ± 5.0 |
| Laboratory values | ||
| Serum creatinine (μmol/L) (mean, SD) | 119.7 ± 91.8 | 170.1 ± 101.5 |
| Serum albumin (g/L) (mean, SD) | 26.6 ± 6.8 | 29.1 ± 7.2 |
| eGFR (mL/minute/1.73 m2) (mean, SD) | 70.8 ± 33.2 | 49.2 ± 34.7 |
| Initial route of administration (% of total) | ||
| Oral | 75 (44.6) | 22 (42.3) |
| Intravenous | 93 (55.4) | 30 (57.7) |
| Cotrimoxazole daily starting dose (% of total) (mg) | ||
| ≤960 | 10 (6.0) | 6 (11.5) |
| 1,920–2,400 | 27 (16.1) | 19 (36.6) |
| 2,880 | 15 (8.9) | 6 (11.5) |
| 3,840–4,800 | 35 (20.8) | 7 (13.5) |
| 5,760 | 81 (48.2) | 14 (27.0) |
| Co‐medication | ||
| Corticosteroids (% of total) | 62 (36.9) | 18 (34.6) |
| Comorbidities | ||
| Continuous renal replacement therapy (count, %) | 18 (10.7) | 14 (27%) |
| Stem‐cell transplantation (% of total) | 13 (7.7) | 3 (5.8) |
| Solid organ transplantation (% of total) | 35 (20.8) | 24 (46.2) |
| Malignancy (% of total) | 23 (13.7) | 6 (11.5) |
| HIV (% of total) | 19 (11.3) | 0 (0.0) |