Table 3.

Model parameters sulfamethoxazole

Parameter	Estimate	RSE (%)	Bootstrap median	95% CI
Sulfamethoxazole
Biological availability	1 Fixed		1 Fixed
Absorption rate constant	0.978	45	0.95	0.25–8.61
Apparent clearance (L/hour)a	0.97	4	0.97	1.06
eGFR on CL	0.27	20	0.28	0.16–0.38
CRRT on CL	2.2	10	2.2	1.8–2.6
Volume of distribution (L)	37.0	6	36.8	21.5–43.3
IIV CL (%)	36.3	8	36.5	29.6–42.4
IIV Vd (%)	62.9	11	60.2	37.4–79.4
N‐acetyl sulfamethoxazole
Conversion parent metabolite	0.4 × CL
Apparent clearance (L/hour)a	1.34	4	1.33	1.21–1.43
eGFR on CL	0.797	7	0.79	0.65–0.92
CRRT on CL	0.683	11	0.68	0.54–0.86
Volume of distribution (L)	3.98	24	3.87	1.55–6.33
IIV CL (%)	40.7	8	40.9	34.5–48.3
Proportional error
Sulfamethoxazole	0.181	8	0.178	0.144–0.208
N‐acetyl sulfamethoxazole	0.201	8	0.194	0.155–0.230

^aFormula for clearance: in case of no CRRT = 0.97 × (EGFR/68)^0.27 in case of CRRT: 1.34 × 2.2.

Formula for clearance of the metabolite in case of no CRRT = 1.34 × (EGFR/68)^0.797 in case of CRRT: 1.34 × 0.683.