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. 2024 Aug 15;117(1):184–192. doi: 10.1002/cpt.3421

Table 4.

Dose adjustments in patients with a reduced eGFR or treated with CRRT

Estimated glomerular filtration rate Dose required to reach equivalent exposure to a patient with an eGFR of 70 mL/minute/1.73 m2 Lowest simulated dose with >25% of the simulated patients above the upper limit of the target concentrations
50 mL/minute/1.73 m2 100% TID 1,920 mg
30 mL/minute/1.73 m2 83.3% b.i.d. 1,920 mg
10 mL/minute/1.73 m2 66.7% b.i.d. 1,440 mg
CRRT

200% for sulfamethoxazole

100% for trimethoprim

 b.i.d. 2,400 mg