Table 9.

ADMET prediction of the top ten selected compounds from Chloranthus elatior leaf extract.

L/N	Absorption		Distribution		Metabolism		Excretion		Toxicity
Ligand no.	Lipophilicity	Intestinal absorption (human) Yes/No 75 %+	BBB permeability Yes/No	CNS Permeability (log PS)	CYP3A4substrate (Yes/No)	CYP3A4 inhibitor (Yes/No)	Total Clearance(ml/min/kg)	Renal OCT2 substrate((Yes/No)	Max. Tolerated dose (human) mg/kg/day	Hepatotoxicity
L-10	0.99	98.59	−1.10	−3.22	Yes	No	−0.77	No	−1.63	No
L-17	2.82	92.29	−0.39	−2.94	No	Yes	0.52	No	0.55	No
L-01	2.30	95.80	0.36	−2.86	No	No	1.12	No	0.35	No
L-03	2.68	99.06	0.09	−2.73	No	No	0.58	No	0.18	No
L-06	1.88	97.21	0.07	−2.88	No	No	0.96	No	0.27	No
L-07	0.99	75.19	0.11	−2.98	No	No	1.00	No	0.40	No
L-22	2.18	99.07	0.65	−2.43	Yes	No	0.47	Yes	0.18	No
L-04	2.56	99.38	0.09	−2.73	No	No	1.05	No	0.19	No
L-15	3.31	92.32	−0.32	−2.36	Yes	Yes	0.32	No	0.89	No
L-09	1.55	95.96	−0.24	−2.97	No	No	1.01	No	0.44	No

Note: Log P = High Lipophilicity (acceptance range: <5).