Table 1.
Baseline characteristics of the study population (n = 987) and in quartiles of TNFR1 (pg/mL).
| Variable | Quartiles | P | ||||
|---|---|---|---|---|---|---|
| All | 1 (lowest) | 2 | 3 | 4 (highest) | ||
| Number of patients | n = 987 | n = 248 | n = 246 | n = 247 | n = 246 | |
| Mean (SD) | ||||||
| TNFR1 (pg/mL) | 4560 (2572) | 2047 (495) | 3362 (356) | 4797 (493) | 8040 (2431) | - |
| Age (years) | 63 (14) | 62 (13) | 62 (14) | 64 (15) | 65 (15) | 0.11 |
| Creatinine (µmol/L) | 228 (127) | 140 (41) | 192 (67) | 245 (112) | 336 (157) | <0.001 |
| eGFR creatinine (mL/min/1.73 m2) | 31 (16) | 46 (16) | 33 (12) | 26 (13) | 19 (11) | <0.001 |
| Cystatin C (mg/L) | 2.7 (1.2) | 1.9 (0.9) | 2.4 (0.9) | 2.9 (0.9) | 3.6 (1.1) | <0.001 |
| eGFR Cystatin C (mL/min/1.73 m2) | 26 (15) | 40 (17) | 27 (11) | 22 (11) | 16 (9.2) | <0.001 |
| Systolic blood pressure (mmHg) | 138 (21) | 137 (22) | 136 (20) | 137 (22) | 140 (22) | 0.16 |
| Diastolic blood pressure (mmHg) | 76 (12) | 77 (12) | 75 (12) | 75 (12) | 75 (12) | 0.09 |
| U-protein (g/L) | 0.48 (0.83) | 0.20 (0.36) | 0.41 (0.74) | 0.54 (0.88) | 0.75 (1.06) | <0.001 |
| C-reactive protein (mg/L) | 7.97 (15.88) | 4.71 (6.85) | 6.22 (9.62) | 7.33 (12.34) | 13.61 (25.95) | <0.001 |
| N (%) | P | |||||
| Females | 363 (37) | 90 (37) | 78 (32) | 107 (44) | 88 (37) | 0.07 |
| Previous cardiovascular disease | 283 (29) | 62 (26) | 78 (32) | 69 (28) | 74 (31) | 0.45 |
| Smoking, current or previous | 627 (65) | 146 (60) | 155 (64) | 164 (67) | 162 (67) | 0.35 |
| Diabetes | 286 (29) | 50 (21) | 80 (33) | 79 (32) | 77 (32) | 0.007 |
| Heart failure | 154 (16) | 20 (8) | 39 (16) | 41 (17) | 54 (22) | 0.008 |
SD: standard deviation; eGFR: estimated glomerular filtration rate.
The P-value shows differences between quartiles of TNFR1.