Table 2.
Baseline characteristics of the study population (n = 984) and in quartiles of TNFR2 (pg/mL).
| Variable | Quartiles | P | |||||
|---|---|---|---|---|---|---|---|
| All | 1 (lowest) | 2 | 3 | 4 (highest) | |||
| Number of patients | n = 984 | n = 247 | n = 245 | n = 246 | n = 246 | ||
| Mean (SD) | |||||||
| TNFR2 (pg/mL) | 12441 (7062) | 6583 (1274) | 9725 (903) | 13029 (1092) | 20453 (9480) | - | |
| Age (years) | 63 (14) | 62 (14) | 64 (14) | 63 (14) | 65 (14) | 0.015 | |
| Creatinine (µmol/L) | 229 (127) | 143 (49) | 191 (74) | 252 (114) | 327 (157) | <0.001 | |
| eGFR creatinine (mL/min/1.73 m2) | 31 (16) | 46 (16) | 33 (13) | 25 (12) | 19 (10) | <0.001 | |
| Cystatin C (mg/L) | 2.7 (1.2) | 1.9 (1.0) | 2.5 (0.9) | 3.0 (1.0) | 3.4 (1.0) | <0.001 | |
| eGFR Cystatin C (mL/min/1.73 m2) | 26 (15) | 39 (17) | 28 (13) | 20 (10) | 17 (9.2) | <0.001 | |
| Systolic blood pressure (mmHg) | 138 (21) | 136 (21) | 135 (20) | 139 (21) | 140 (23) | 0.39 | |
| Diastolic blood pressure (mmHg) | 76 (12) | 77 (12) | 74 (11) | 76 (12) | 75 (12) | 0.45 | |
| U-protein (g/L) | 0.48 (0.83) | 0.19 (0.31) | 0.36 (0.59) | 0.51 (0.69) | 0.86 (1.28) | <0.001 | |
| C-reactive protein | 7.99 (15.90) | 4.27 (6.89) | 6.15 (9.78) | 8.40 (15.76) | 13.25 (24.13) | <0.001 | |
| N (%) | P | ||||||
| Females | 363 (37) | 87 (36) | 91 (38) | 103 (42) | 82 (34) | 0.24 | |
| Previous cardiovascular disease | 283 (29) | 60 (25) | 64 (27) | 76 (31) | 83 (34) | 0.16 | |
| Smoking, current or previous | 625 (65) | 143 (59) | 150 (63) | 162 (66) | 170 (70) | 0.06 | |
| Diabetes | 286 (29) | 59 (24) | 67 (28) | 86 (35) | 74 (30) | 0.06 | |
| Heart failure | 154 (16) | 33 (14) | 30 (13) | 32 (13) | 59 (24) | 0.001 | |
SD: standard deviation; eGFR: estimated glomerular filtration rate.
The P-value shows differences between quartiles of TNFR2.