Table 3.
Associations between TNFR1 and TNFR2 and all-cause mortality risk in Cox regression models.
| Continuous | Quartiles | ||||
|---|---|---|---|---|---|
| 1 SD-increase HR (95% CI) | 1 (lowest) HR (95% CI) | 2 HR (95% CI) | 3 HR (95% CI) | 4 (highest) HR (95% CI) | |
| TNFR1 | |||||
| Number of events/numbers at risk | 542/971 | 100/242 | 134/243 | 144/245 | 164/241 |
| Unadjusted model | 1.42*** (1.31–1.55) | referent | 1.52** (1.18–1.96) | 1.78*** (1.38–2.28) | 1.51*** (1.96–3.20) |
| Model A (age, gender) | 1.46*** (1.34–1.60) | referent | 1.55** (1.20–2.00) | 1.79*** (1.39–2.31) | 2.61*** (2.02–3.36) |
| Model B (inflammation) | 1.40*** (1.28–1.54) | referent | 1.51** (1.17–1.95) | 1.73*** (1.34–2.23) | 2.37*** (1.83–3.08) |
| Model C (CVD risk factors) | 1.43*** (1.30–1.57) | referent | 1.49** (1.15–1.93) | 1.73*** (1.34–2.24) | 2.42*** (1.87–3.14) |
| Model D (Model A+B+C) | 1.38*** (1.25–1.53) | referent | 1.46** (1.13–1.89) | 1.68*** (1.30–2.18) | 2.22*** (1.70–2.90) |
| Model E (all combined + eGFR + urine Protein) | 1.15 (1.00–1.31) | referent | 1.21 (0.91–1.59) | 1.17 (0.85–1.60) | 1.31 (0.92–1.87) |
| TNFR2 | |||||
| Number of events/numbers at risk | 542/968 | 91/244 | 127/237 | 149/244 | 175/243 |
| Unadjusted model | 1.40*** (1.30–1.51) | referent | 1.62*** (1.24–2.10) | 2.00*** (1.54–2.59) | 3.04*** (2.36–3.90) |
| Model A (age, gender) | 1.48*** (1.36–1.60) | referent | 1.60** (1.23–2.10) | 2.00*** (1.53–2.61) | 3.02*** (2.34–3.89) |
| Model B (inflammation) | 1.35*** (1.20–1.51) | referent | 1.55** (1.18–2.02) | 1.90*** (1.45–2.49) | 2.76*** (2.12–3.58) |
| Model C (CVD risk factors) | 1.44*** (1.32–1.57) | referent | 1.63*** (1.25–2.14) | 1.92*** (1.47–2.52) | 2.86*** (2.21–3.69) |
| Model D (A + B + C) | 1.40*** (1.29–1.53) | referent | 1.58** (1.21–2.07) | 1.81*** (1.38–2.38) | 2.64*** (2.03–3.44) |
| Model E (all combined+ eGFR + urine-protein) | 1.17* (1.03–1.34) | referent | 1.33* (1.00–1.76) | 1.32 (0.96–1.82) | 1.64** (1.16–2.32) |
HR: hazard ratio; CI: confidence interval; SD: standard deviation; eGFR: estimated glomerular filtration rate; CVD: cardiovascular disease
Hazard ratio calculated based on 7424 person-years at risk;
***
P < 0.001;
**
P < 0.01;
*
P < 0.05.
Model A: Adjusted for age and gender. Model B: Adjusted for age, gender, and C-reactive protein. Model C: Adjusted for age, gender, systolic blood pressure, diastolic blood pressure, smoking status, heart failure, diabetes, and prevalent cardiovascular disease.
Model D: Model A + B + C combined. Model E: Model A+B+C+baseline eGFR and u-protein.