Table 1.
Genes associated with hearing loss and their expression sites.[ 20 ]
| Expression site | Gene symbol |
|---|---|
| Tectorial membrane | Cldn14, Ceacam16, Col2a1, Col9a1, Col9a3, Col11a1, Otog, Otogl, Tecta |
| Interdental cell | Gjb2, Gjb6, Ceacam16, Edn3, Clic5, Wfs1, Otoa, Otog, Otogl, Chd7, Eya1, Sox10 |
| Spiral limbus | Myh9, Gjb2, Gjb3, Gjb6, Esrrb, P2rx2, Wfs1, Col2a1, Col4a3, Col4a5, Col9a1, Col9a3, Col11a2, Otoa, Chd7, Eya1, Eya4, Serpinb6, Ccdc50 |
| Inner sulcus cell | Myh9, Gjb2, Gjb6, Edn3, Wfs1, Col4a3, Col4a4, Col4a5, Eya1, Eya4, Sox10, Adcy1, Clpp, Serpinb6 |
| Spiral ganglion | Edn3, Esrrb, P2rx2, Slc17a8, Wfs1, Col4a6, Chd7, Eya1, Eya4, Pax3, Sox10, Cabp2, Tbc1d24, Gipc3, Kars, Msrb3, Pnpt1, Prps1, Tmprss3, Clrn1, Dfnb59, Otof, Tbc1d24, Tspear, Mir96 |
| Inner hair cell | Actg1, Espn, Rdx, Syne4, Triobp, Myh14, Myo3a, Myo6, Myo7a, Myo15a, Cdh23, Pcdh15, Cldn14, Marveld2, Tjp2,Ceacam16, Gpr98, Pdzd7, Tprn, Ush1c, Whrn, Edn3, Ednrb, Eps8, Esrrb, Ildr1, Vlgr1, Clic5, Lhfpl5, Loxhd1, P2rx2, Slc17a8, Tmc1, Wfs1, Otoa, Otogl, Strc, Chd7, Eya1, Pou4f3, Six1, Cabp2, Cib2, Gpsm2, Adcy1, Clpp, Gipc3, Grxcr1, Grxcr2, Kars, Lrtomt/Comt2, Msrb3, Pnpt1, Prps1, Ptprq, Serpinb6, Tmprss3, Clrn1, Dfnb59, Elmod3, Mir96, Otof, Ush2a, Sans, Smac/Diablo, Smpx,Tbc1d24, Tmie, Tspear |
| Supporting cell | Myh9, Myh14, Syne4, Triobp, Gjb2, Gjb6, Cldn14, Tjp2, Ceacam16, Tprn, Esrrb, Ildr1, Lhfpl5, P2rx2, Wfs1, Otogl, Eya1, Sox10, Cib2, Gpsm2, Adcy1, Clpp, Grxcr1, Kars, Lrtomt/Comt2, Msrb3, Pnpt1, Ccdc50, Elmod3, Smpx, Tmie |
| Outer hair cell | Actg1, Espn, Rdx, Syne4, Triobp, Myo3a, Myo6, Myo7a, Myh9, Myh14, Myo15a, Cdh23, Pcdh15, Cldn14, Marveld2, Tjp2, Ceacam16, Gpr98, Pdzd7, Tprn, Ush1c, Whrn, Edn3, Esrrb, Eps8, Ildr1, Vlgr1, Clic5, Kcnq4, Lhfpl5, Loxhd1, P2rx2, Slc26a5, Tmc1, Wfs1, Otogl, Strc, Chd7, Eya1, Pou4f3, Six1, Cabp2, Cib2, Gpsm2, Adcy1, Clpp, Gipc3, Grxcr1, Grxcr2, Kars, Lrtomt/Comt2, Msrb3, Pnpt1, Prps1, Ptprq, Serpinb6, Ccdc50, Clrn1, Dfnb59, Elmod3, Mir96, Otof, Sans, Smac/Diablo, Smpx, Tbc1d24, Tmie, Tspear, Ush2a |
| External sulcus cell | Myh9, Myh14, Gjb2, Gjb6, Slc26a4, Wfs1, Coch, Col4a3, Col4a4, Col4a5, Col11a1, Col11a2, Eya4, Sox10, Serpinb6 |
| Stria vascularis | Myh14, Gjb2, Gjb6, Marveld2, Edn3, Esrrb, Kcne1, Kcnj10, Kcnq1, Wfs1, Col4a3, Col4a5, Col4a6, Col11a1, Col11a2, Chd7, Eya1, Grhl2, Pax3, Six1, Sox10, Serpinb6, Bdp1, Ccdc50, Ndp, Tmie, Tsper |
| Spiral ligament | Myh9, Myh14, Gjb2, Gjb3, Gjb6, Esrrb, Wfs1, Coch, Col4a3, Col4a4, Col4a5, Col4a6, Col9a1, Col9a3, Col11a1, Col11a2, Chd7, Eya1, Pou3f4, Crym, Serpinb6, Bdp1, Ccdc50 |
| Reissner's membrane | Myh9, Cdh23, Cldn14, Tprn, Esrrb, P2rx2, Wfs1, Col4a3, Col4a5, Chd7, Eya1, Grhl2, Pou3f4, Sox10, Bdp1, Grhl2, Tmie |