Table 3.

Transduction rates of commonly used AAV capsids to different cells of the inner ear.

Common AAV Serotypes	Stage	Hair Cell		Supporting Cell
		IHC	OHC
AAV1[ 46 , 52 ]	neonatal	+++++	++	−
	adult	++	∖	+
AAV2[ 46 , 52 , 53 , 54 ]	neonatal	++++	+++	+
	adult	++++	++	+
AAV8[ 55 ]	neonatal	++++	++	+
	adult	++++	+	‐
AAV9[ 46 , 52 , 56 ]	neonatal	++++	+++	+
	adult	+++	∖	+
AAV‐S[ 57 ]	neonatal	+++++	++	+
	adult	+++++	++	−
AAV‐DJ[ 58 , 59 ]	neonatal	+++	+	+++
AAV‐PHP.eB[ 58 , 60 ]	neonatal	+++++	++++	∖
AAV2.7m8[ 61 ]	neonatal	++++	+++	+
	adult	++++	++++	−
Anc80L65[ 62 , 63 , 64 , 65 ]	embryonic	++++	++++	+++
	neonatal	+++++	++++	−
	adult	+++++	+++	−
AAV‐ie[ 65 ]	neonatal	++++	+++	++++
	adult	++++	−	++++
AAV‐PHP.B[ 66 ]	neonatal	+++	++	−
	adult	++++	∖	−

“+” indicates the infection efficiency of each commonly used serotype against different cell types in mice of different ages.; “−” indicates that the experiments in the literature did not explicitly draw relevant conclusions.; “∖” indicates that the experiments in the literature resulted in almost no transduction or total death.; IHC: inner hair cell. OHC: the outer hair cell.