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. 2024 Nov 13;11(47):2403627. doi: 10.1002/advs.202403627

Figure 8.

Figure 8

Applications of developmental transcriptional profiles in dental dysplasia. a) Heatmap representing the expression level of cell‐type specific dental dysplasia genes summarized from dental dysplasia HPO phenotype terms. b) Cell source analysis representing selected genes related to dental dysplasia. Graph abstraction overlay of cluster expression of disease genes associated with (i) abnormal dental enamel morphology (APC4 and APC), (ii) abnormal dentin morphology (IFITM5), (iii) tooth malposition (AEBP1), and (iv) abnormal dental eruption (ANTXR1). c) Violin plots representing individual time‐course variations in dysplasia‐associated gene expression for abnormal dental enamel morphology and abnormal dentine morphology. APC and AKT1 expression over time in IEE_OEE cells are shown above. IFITM5 and FKBP10 expression over time in odontoblasts are shown below.