TABLE 1.
Clinical and radiological characteristics of patients with high-grade GMH-IVH
| Clinical Characteristic | High-Grade (n = 43) | Grade III (n = 12) | Grade IV (n = 31) | p Value* |
|---|---|---|---|---|
| Estimated GA, wks | 25.0 (1.9) | 25.2 (1.5) | 24.9 (2.1) | 0.69 |
| Male sex, n (%) | 29 (67.4) | 10 (83.3) | 19 (61.3) | 0.28 |
| Birth weight, g | 835.2 (178.9) | 852.5 (132.8) | 828.6 (195.3) | 0.70 |
| FTHR | 0.52 (0.08) | 0.50 (0.06) | 0.52 (0.09) | 0.48 |
| Medical risk index, median (IQR) | 3 (2–5) | 3 (2.5–6) | 3 (2–5) | 0.50 |
| Sociodemographic stressor index, median (IQR) | 2 (0–3) | 2 (0–3) | 2 (0–3) | 0.94 |
| General anesthesia events | 3.8 (3.6) | 4.6 (2.9) | 3.5 (3.8) | 0.32 |
| Bayley-III score | ||||
| Cognition | 75.9 (12.7) | 81.7 (11.9) | 73.7 (12.5) | 0.07 |
| Language | 73.7 (25.5) | 82.8 (13.5) | 70.2 (28.3) | 0.06 |
| Motor | 68.6 (17.0) | 68.4 (24.4) | 68.7 (13.6) | 0.98 |
| CP diagnosis, n (%) | 30 (69.8) | 9 (75.0) | 21 (67.7) | 0.73 |
| Needs assistance w/ ADLs, n (%)† | 11 (28.2) | 2 (20.0) | 9 (31.0) | 0.69 |
| Walks freely w/o assistance, n (%) | 32 (74.4) | 10 (83.3) | 22 (71.0) | 0.70 |
| Symmetric gait, n (%) | 26 (60.5) | 10 (83.3) | 16 (51.6) | 0.08 |
| Toe-walking, n (%)† | 20 (51.3) | 6 (54.5) | 14 (50.0) | 0.99 |
| Shunt placement, n (%) | 19 (44.2) | 6 (50.0) | 13 (41.9) | 0.74 |
| Hemorrhage vol, cm3 | ||||
| Lt GMH vol | 0.14 (0.14) | 0.07 (0.06) | 0.17 (0.16) | 0.006 |
| Rt GMH vol | 0.29 (0.42) | 0.09 (0.10) | 0.36 (0.47) | 0.004 |
| Lt PVHI vol | —‡ | 0.98 (1.07) | — | |
| Rt PVHI vol | — | 1.68 (2.22) | — |
CP = cerebral palsy.
Values are given as mean (SD) unless otherwise indicated. Boldface type indicates statistical significance (p < 0.05).
*
Calculated using Student’s t-test for continuous variables and Fisher’s exact test for categorical variables.
†
Excludes 4 patients with missing data.
‡
Not applicable as grade III by definition does not have PVHI.