TABLE 2.

Clinical and radiologic factors and their association with neurodevelopmental outcomes

	Bayley-III Score*
	Cognition			Language			Motor
	Estimated Change	SE	p Value	Estimated Change	SE	p Value	Estimated Change	SE	p Value
Unadjusted linear regression model
Estimated GA, wks	+0.93	1.04	0.37	−0.319	1.334	0.812	+1.353	1.077	0.216
Male sex	−2.33	4.18	0.58	−3.012	5.523	0.589	+2.893	4.392	0.514
Birth weight, g	+0.02	0.01	0.18	0.014	0.015	0.336	+0.022	0.011	0.057
Medical risk index	−1.98	0.99	0.054	−2.494	1.248	0.053	−2.348	1.024	0.027
Sociodemographic stressor index	−0.38	1.29	0.77	−1.694	1.713	0.329	−0.092	1.367	0.946
No. of general anesthesia events	−1.19	0.53	0.030	−0.804	0.698	0.257	−1.541	0.534	0.006
FTHR	−13.7	24.0	0.57	−4.6	48.3	0.92	−14.8	32.1	0.65
GMH vol, cm3
Lt	−36.45	13.32	0.009	−27.087	18.185	0.145	−42.403	13.611	0.003
Rt	−7.941	4.802	0.106	−6.469	6.282	0.310	−7.532	4.900	0.133
Total	−9.061	3.998	0.029	−8.069	5.247	0.132	−10.382	4.148	0.017
PVHI vol, cm3
Lt	−2.224	3.085	0.481	−4.620	4.505	0.322	−3.844	2.824	0.192
Rt	−2.302	1.202	0.072	−2.260	1.616	0.181	−3.265	1.403	0.033
Multivariable model
GMH vol, cm3
Lt†	−28.8	14.0	0.048	−21.9	19.3	0.268	−35.8	13.1	0.010
Rt†	−7.30	4.89	0.145	−8.76	6.78	0.206	−6.23	4.61	0.186
Total‡	−9.85	4.17	0.023	−11.0	5.54	0.054	−10.8	4.21	0.014
PVHI vol, cm3
Lt§	−2.35	3.20	0.474	−4.39	4.69	0.367	−3.80	2.94	0.215
Rt§	−2.23	1.19	0.080	−2.19	1.65	0.204	−3.21	1.43	0.039
Lt¶	−4.30	3.26	0.206	−7.02	5.05	0.188	−6.36	2.80	0.038
Rt¶	−2.03	1.22	0.114	−2.23	1.69	0.208	−2.90	1.40	0.055
Lt**	−2.53	2.70	0.363	−4.57	2.46	0.85	−4.09	2.60	0.137
Rt**	−2.48	1.05	0.031	−2.34	1.64	0.173	−3.46	1.26	0.014
Lt††	−0.244	3.16	0.939	−2.99	4.83	0.547	−2.26	2.94	0.461
Rt††	−1.60	1.20	0.203	−1.97	1.75	0.278	−2.48	1.42	0.099

Boldface type indicates statistical significance (p < 0.05).

^*Estimated change of composite score with 1 unit increasing in the continuous factors or estimated score difference between two groups (yes minus no) for categorical factors.

^†Controlling for medical risk index, number of general anesthesia events, and contralateral GMH volume.

^‡Controlling for medical risk index and number of general anesthesia events.

^§Controlling for presence of contralateral GMH volume.

^¶Controlling for presence of contralateral PVHI volume.

^**Controlling for medical risk index.

^††Controlling for number of general anesthesia events.