Table 1.
Demographics, illness severity and comorbidities stratified by sex
| Variable | Overall n = 8950 | Women n = 3811 | Men n = 5139 |
|---|---|---|---|
| Age | 68.0 [56.0–79.0] | 71.0 [58.0–81.0] | 66.0 [54.0–77.0] |
| Comorbidity and Illness severity scores | |||
| Charlson Comorbidity Index | 5.0 [3.0–7.0] | 5.0 [3.0–7.0] | 5.0 [3.0–7.0] |
| SAPS II | 39.0 [31.0–49.0] | 39.0 [31.0–50.0] | 38.0 [30.0–49.0] |
| Diagnosis and admission type | |||
| Sepsis at admission | 6477 (72.4%) | 2699 (70.8%) | 3778 (73.5%) |
| Type of admission | |||
| Cardiac Vascular Intensive Care Unit (CVICU) | 1077 (12.0%) | 378 (9.9%) | 699 (13.6%) |
| Coronary Care Unit (CCU) | 846 (9.5%) | 322 (8.4%) | 524 (10.2%) |
| Medical Intensive Care Unit (MICU) | 2320 (25.9%) | 1003 (26.3%) | 1317 (25.6%) |
| Medical/Surgical Intensive Care Unit (MICU/SICU) | 1202 (13.4%) | 570 (15.0%) | 632 (12.3%) |
| Neuro Surgical Intensive Care Unit (Neuro SICU) | 420 (4.7%) | 183 (4.8%) | 237 (4.6%) |
| Neurology | 702 (7.8%) | 335 (8.8%) | 367 (7.1%) |
| Surgical Intensive Care Unit (SICU) | 1239 (13.8%) | 578 (15.2%) | 661 (12.9%) |
| Trauma SICU (TSICU) | 1144 (12.8%) | 442 (11.6%) | 702 (13.7%) |
| ICU—treatment administered before delirium onset | |||
| Invasive ventilation before onset of delirium | 4593 (51.3%) | 1843 (48.4%) | 2750 (53.5%) |
| Renal replacement therapy before onset of delirium | 730 (8.2%) | 306 (8.0%) | 424 (8.3) |
| Vasoactive medication* before onset of delirium | 4039 (45.1%) | 1665 (43.7%) | 2374 (46.2%) |
| Sedation with benzodiazepines before onset of delirium | 2426 (27.1%) | 993 (26.1%) | 1433 (27.9%) |
| Transfusion of pRBCs before onset of delirium | 2576 (28.8%) | 1159 (30.4%) | 1417 (27.6%) |
| Comorbidities | |||
| Peripheral vascular disease | 1008 (11.3%) | 382 (10.0%) | 626 (12.2%) |
| Coronary artery disease | 1507 (16.8%) | 533 (14.0%) | 974 (19.0%) |
| Cerebrovascular disease | 1961 (21.9%) | 923 (24.2%) | 1038 (20.2%) |
| Congestive heart failure | 2478 (27.7%) | 1057 (27.7%) | 1421 (27.7%) |
| Renal disease | 1750 (19.6%) | 645 (16.9%) | 1105 (21.5%) |
| Dementia | 671 (7.5%) | 346 (9.1%) | 325 (6.3%) |
| Chronic pulmonary disease | 2226 (24.9%) | 1104 (29.0%) | 1122 (21.8%) |
| Malignant cancer | 1004 (11.2%) | 386 (10.1%) | 618 (12.0%) |
| Rheumatic disease | 276 (3.1%) | 185 (4.9%) | 91 (1.8%) |
| Peptic ulcer disease | 252 (2.8%) | 107 (2.8%) | 145 (2.8%) |
| Mild liver disease | 1201 (13.4%) | 424 (11.1%) | 777 (15.1%) |
| Severe liver disease | 630 (7.0%) | 225 (5.9%) | 405 (7.9%) |
| Diabetes without complications | 1981 (22.1%) | 836 (21.9%) | 1145 (22.3%) |
| Diabetes with complications | 916 (10.2%) | 330 (8.7%) | 586 (11.4%) |
| Paraplegia | 838 (9.4%) | 388 (10.2%) | 450 (8.8%) |
| Metastatic solid tumor | 449 (5.0%) | 189 (5.0%) | 260 (5.1%) |
| Acquired immune deficiency syndrome (AIDS) | 35 (0.4%) | 10 (0.3%) | 25 (0.5%) |
For continuous variables medians with 25th–75th percentile in brackets are depicted, whereas for categorical variables absolute values and percent in brackets are presented
*Vasoactive medication was defined as infusion of dopamine, epinephrine, norepinephrine, phenylephrine, vasopressin, dobutamine or milrinone for at least 10 consecutive minutes or longer
AIDS Acquired immune deficiency syndrome; CCU Coronary Care Unit; CVICU Cardiac Vascular Intensive Care Unit; MICU Medical Intensive Care Unit; MICU/SICU Medical/Surgical Intensive Care Unit; Neuro SICU Neuro Surgical Intensive Care Unit; pRBCs Packed red blood cells; SAPS II Simplified Acute Physiology Score II; SICU Surgical Intensive Care Unit; TSICU Trauma SICU