Fig. 1.

Cell-type composition of lung tissues in the Lung Tissue Research Consortium derived using RNA sequencing deconvolution

Boxplots show cell type abundance score for each cell type split by disease status. Results are shown only for cell types detected in at least 10% of samples, and the median proportion was greater than 1%. Statistical comparison was tested using linear regression adjusting for age, sex, ever-smoking and total pack-year. The asterisk (*) and cross sign (†) denote significant differences (FDR < 0.05) between COPD vs. control and IPF vs. control, respectively. Abbreviations: COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; ATI, alveolar epithelial type 1 cells; ATII, alveolar epithelial type 2 cells; cDC, classical dendritic cells; ILC, innate lymphoid cells; pDC, plasmacytoid dendritic cells; ncMonocyte, non-classical monocytes; SMC; smooth muscle cells; VE Capillary A, vascular endothelial - aerocyte capillary; VE Capillary B, vascular endothelial - general capillary; VE Venous, venous vascular endothelial