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. 2024 Dec 18;26:212. doi: 10.1186/s13075-024-03424-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — WT and Tlr4^Lyz2male and female serum mice show increases in peripheral nerve fibers. Representative confocal images of ankle joint Sects. (20 μm-thick) stained for (A) CGRP (marker of a subtype of sensory axons; cyan), (B) TH (marker of sympathetic axons; purple) and (C) GAP43 (marker of nerve fibers undergoing regeneration; yellow). D-F Male Tlr4^Lyz2 mice had a significant increase in TH⁺(p = 0.0007) and CGRP⁺ (p = 0.0032) fibers but not GAP43⁺ (p = 0.088) fibers and female Tlr4^Lyz2 mice had significant increases in TH⁺ (p = 0.0026), CGRP⁺ (p = 0.0001) and GAP43⁺ (p = 0.0007) fibers (*p < 0.04, Student t test; n = 5–6 per group)