Table 2.
Characteristics of individuals who died of COVID-19 related infection
| Characteristic | ADTKD-MUC1 | ADTKD-UMOD | P-value |
|---|---|---|---|
| Individuals (n) | 19 | 3 | |
| Gender (n male (%)) | 11 (58%) | 2 (67%) | 0.89 |
| Age, years (mean ± sd (median)) | 56.49 ± 8.45 (57.62) | 71.44 ± 7.25 (74.80) | 0.0002 |
| Age > 60 years (n (%)) | 7 (37%) | 3 (100%) | < 0.0001b |
| Body mass index, kg/m2 (mean ± sd (median)) | 30.78 ± 6.46 (30.74) | 25.56 ± 2.02 (25.11) | 0.02 |
| Kidney transplanted (n (%)) | 16 (84%) | 3 (100%) | 0.46b |
| Pre-kidney failure (n (%)) | 2 (11%) | 0 | 0.01b |
| No vaccination (n (percent of those reporting vaccination status) | 11/16 (69%) | 1 (33%) | 0.23 |
| Heart failure | 0/18 | 0/3 | --- |
| Chronic obstructive pulmonary disease or asthma | 1/18 | 0/3 | 0.14b |
| Diabetes mellitus | 4/18 | 0/3 | 0.14b |
| Active malignancy | 0/18 | 0/3 | --- |
| Past malignancyc | 3/18 | 1/3 | 0.15b |
| Average length of hospital stay (mean ± sd (median)) | 18.67 ± 10.80 (21) | 12 ± 5 (12) | 0.15 |
| Required mechanical ventilation | 18/18 (100%) | 2 (67%) | 0.01b |
| Years of kidney failurea (mean ± sd (median)) | 12.86 ± 10.84 (9) | 21.93 ± 14.96 (13.76) | 0.45 |
| > 10 years kidney failurea | 9/17 (53%) | 3 (100%) | 0.003b |
aYears of kidney failure are years from start of kidney failure until contracting COVID-19
bP-values calculated using permutation test
CPast malignancies included Burkitts lymphoma, renal low grade papillary carcinoma, and cervical cancer in ADTKD-MUC1 and breast cancer in ADTKD-UMOD