FIG. 5.

Histopathology of tissue sections from liver and spleen of M. avium-infected mice. Mice were infected with M. avium and treated with anti-CD40L MAb or control IgG. Mice from both groups were sacrificed on day 35. The spleen and liver was collected from each mouse, sectioned (5 μm), and stained with hematoxylin-eosin. The sections were viewed at a magnification of ×100. (A) Spleen from uninfected mouse showing intact white pulp; (B) spleen from M. avium-infected mouse treated with control IgG showing the disrupted white pulp; (C) spleen from M. avium-infected mouse treated with anti-CD40L MAb also showing disrupted white pulp; (D) liver from uninfected mouse; (E) liver from control IgG-treated M. avium-infected mouse showing granulomas; (F) liver from anti-CD40L treated M. avium-infected mouse showing granulomas.