Table 1 |.

Selected completed clinical trials of oncolytic viruses

Virus type	Drug	Cancer type	Clinical trial number	Phase	Refs.
Adenovirus	CG0070	Bladder cancer	NCT02365818	Phase 2, single group, open label	170
	DNX-2401	Glioblastoma, gliosarcoma	NCT02798406	Phase 2, single group, open label	171
		Brainstem glioma	NCT03178032	Phase 1, single group, open label	172
	NSC-CRAd-S-p7	Glioma	NCT03072134	Phase 1, open label	173
Picornavirus	PVSRIPO	Melanoma	NCT03712358	Phase 1, non-randomized, open label	174
	SVV-001	Solid tumours with neuroendocrine features	NCT00314925	Phase 1, non-randomized, open label	175
	CVA21 (CAVATAK)	Malignant melanoma	NCT01227551	Phase 2, single group, open label	123
		Uveal melanoma	NCT03408587	Phase 1b, randomized, open label	176
Herpes simplex virus	TVEC	Melanoma	NCT00289016	Phase 2, single group, open label	177
		Melanoma	NCT00769704	Phase 3, randomized, open label	10,178
		Melanoma	NCT01740297	Phase 1/2, randomized, open label	179
	HSV1716	Non-central nervous system solid tumours	NCT00931931	Phase 1, single group, open label	180,181
Parvovirus	H-1PV	Glioblastoma	NCT01301430	Phase 1/2a, single group, open label	182
Poxvirus	JX-594	Melanoma	NCT00429312	Phase 1/2, single group, open label	183
		Hepatocellular carcinoma	NCT00554372	Phase 2a, randomized, open label	184
	GL-ONC1 (Olvi-Vec)	Ovarian cancer, peritoneal carcinomatosis	NCT02759588	Phase 1b/2, single group, open label	185

Data extracted from the Clinicaltrials.gov database using the following keywords: oncolytic virus, adenovirus, poxvirus, coxsackievirus, herpes simplex virus, parvovirus, reovirus, Seneca Valley virus, vesicular stomatitis virus, poliovirus and cancer.