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. 2024 Mar 22;4(6):20230134. doi: 10.1002/EXP.20230134

FIGURE 2.

FIGURE 2

(A) Schematic illustration of Mn2+‐activated cGAS‐STING signaling pathway against DNA virus. (B) Western blot analysis of cGAMP‐induced IRF3 phosphorylation. cGAMP was produced by cGAS (wild‐type, WT; or E225A/D227A mutant, Mt) in the presence of the indicated amounts of dsDNA, MnCl2, or MgCl2. Reprinted with permission.[ 11e ] Copyright 2018, Elsevier Inc. (C) Schematic illustration of the mechanism of CMPs‐induced cGAS‐STING activation. Reprinted with permission.[ 21 ] Copyright 2021, Springer Nature.