Abstract
The enzymically catalysed incorporation of N-acetylneuraminic acid into human platelets, whether suspended in their own citrated plasma or in buffered saline containing 0.17 mM-sucrose, accelerated the uptake of 5-hydroxytryptamine. This acceleration decreased with time. The observations may be explained by assuming that N-acetylneuraminic acid is a component of a transport receptor for 5-hydroxytryptamine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baumgartner H. R. 5-Hydroxytryptamine uptake and release in relation to aggregation of rabbit platelets. J Physiol. 1969 Apr;201(2):409–423. doi: 10.1113/jphysiol.1969.sp008763. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baumgartner H. R., Born G. V. Effects of 5-hydroxytryptamine on platelet aggregation. Nature. 1968 Apr 13;218(5137):137–141. doi: 10.1038/218137a0. [DOI] [PubMed] [Google Scholar]
- Baumgartner H. R., Born G. V. The relation between the 5-hydroxytryptamine content and aggregation of rabbit platelets. J Physiol. 1969 Apr;201(2):397–408. doi: 10.1113/jphysiol.1969.sp008762. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Born G. V., Hume M. Effects of the numbers and sizes of platelet aggregates on the optical density of plasma. Nature. 1967 Sep 2;215(5105):1027–1029. doi: 10.1038/2151027a0. [DOI] [PubMed] [Google Scholar]
- Born G. V., Juengjaroen K., Michal F. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues. Br J Pharmacol. 1972 Jan;44(1):117–139. doi: 10.1111/j.1476-5381.1972.tb07244.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cronberg S., Caen J. P. Platelet aggregation in washed suspensions. Scand J Haematol. 1971;8(3):161–168. doi: 10.1111/j.1600-0609.1971.tb01967.x. [DOI] [PubMed] [Google Scholar]
- Kean E. L., Roseman S. The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase. J Biol Chem. 1966 Dec 10;241(23):5643–5650. [PubMed] [Google Scholar]
- Mester L., Szabados L., Born G. V., Michal F. Changes in the aggregation of platelets enriched in sialic acid. Nat New Biol. 1972 Apr 19;236(68):213–214. doi: 10.1038/newbio236213a0. [DOI] [PubMed] [Google Scholar]
- Michal F., Born G. V., Mester L., Szabados L. Effect of 5-hydroxytryptamine on the potassium ion exchange of human platelets enriched in sialic acid. Biochem J. 1972 Oct;129(4):977–978. doi: 10.1042/bj1290977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schachter H., Jabbal I., Hudgin R. L., Pinteric L., McGuire E. J., Roseman S. Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction. J Biol Chem. 1970 Mar 10;245(5):1090–1100. [PubMed] [Google Scholar]