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. 2024 Dec 18;14(1):217. doi: 10.1038/s41408-024-01173-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A Volcano plot of the transcriptome profile displaying the pattern of differentially expressed genes in PMN (CD11b⁺CD33⁺ HLADR^-/low CD15⁺/CD66b⁺) vs M-MDSCs (CD11b⁺CD33⁺ HLADR^-/low CD14⁺). Significantly expressed genes (log2 fold change ≥ 0.25, adjusted p ≥ 10e-6) are shown in the plot, where red and blue represents upregulated and downregulated genes respectively. B The enrichment score curve shows alteration of pathways involving E2F Targets, G2M checkpoints, Mitotic spindle, and MYC targets. The enrichment score normalized (NES) greater or less than zero shows upregulation and downregulation respectively. The plots were generated using Hallmark GSEA analysis. C Reactome and KEGG GSEA analysis showing significant pathways up and downregulated in PMN vs M-MDSCs. The red bar signifies highly upregulated pathways with high NES values and the green bars show low NES values with downregulated pathways. D qPCR analysis of H1F-α expression in WM vs NBM. E qPCR analysis of MPO, AZU1 and CXCR4 expression in PMN-MDSCs vs M-MDSCs.