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. 2024 Dec 18;14(1):218. doi: 10.1038/s41408-024-01199-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A T/NK cells from NC, ND-AITL and RR-AITL illustrated in UMAP plots, respectively. B Group preference of T cells subtypes, with color encoded by odds ratio estimated by one-sided Fisher’s exact test. *P value < 0.05, **P value < 0.01,***P value < 0.001. The orange color represents enrichment of subpopulation in the sample, while green color represents depletion of subpopulation in the sample. C Immunofluorescence analysis for ND-AITL (left) and RR-AITL (right) samples stained by anti-DAPI (blue), anti-CD8 (green), anti-FOXP3(red) antibodies. Scale bar, 100 μm. D The percentage of selected cell types within IMC dataset between ND-AITL and RR-AITL. E The representative markers for Tfh cells (ICOS; green) and CD8⁺ T cells (CD8α; red) stained in each ROI. F Enrichment scores of pathways related to T cell migration capacity in CD8⁺ T cells from ND-AITL and RR-AITL samples. P values were determined by two-sided unpaired Wilcoxon test. G Enrichment scores of cytotoxic and exhausted signatures of CD8⁺ T cells from ND-AITL and RR-AITL samples. ***P value < 0.001. P values were determined by two-sided unpaired Wilcoxon test. H Violin plots depict the intensities of immune checkpoint molecules in CD8⁺ T cells between seven and eight ROIs from RR-AITL and ND-AITL, respectively. P values were determined by two-sided unpaired Wilcoxon test. I Violin plots showing the intensities of PD-L1 in malignant Tfh cells across seven and eight ROIs in RR-AITL and ND-AITL, respectively. P values were determined by two-sided unpaired Wilcoxon test. J The spearman correlation between YY1 expression and the percentage of CD8⁺ T cells estimated by CIBERSORTx in GSE51521 dataset. Each data point represents individual sample.