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. 2024 Dec 5;15:1440679. doi: 10.3389/fphar.2024.1440679

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Copyright © 2024 Tchaparian, Lin, Chen, Hunter, Yin, Ng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HPLC radio-chromatogram of plasma extracts from female BALB/c Athymic (nu+/nu+) xenograft mice following a single intravenous dose of [14C] CA102N at 200 mg/kg. HPLC radio-chromatogram displays the analysis of plasma extracts from female BALB/c Athymic (nu+/nu+) xenograft mice, pooled from 0 to 24 h following a single intravenous dose of [14C] CA102N at 200 mg/kg. The chromatogram demonstrates the presence of radiolabeled components, with the predominant peak corresponding to the parent compound, CA102N, indicating that the parent drug remains the predominant component in plasma during this period.