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. 2024 Dec 5;15:1440679. doi: 10.3389/fphar.2024.1440679

TABLE 1.

Distribution profile of total radioactivity (μg equivalents per gram tissue) determined by QWBA in tumors and major mouse tissues after i.v. administration of 200 mg/kg [14C] CA102N to the tumor-bearing mice (n = 1 per time point).

Tissue (µg equiv/g)
Time (h) Lung total tumor Bone Marrow Lymph Node Spleen kidney Liver Heart (myocardium)
0.5 885.00 608.05 260.58 162.05 185.07 961.30 199.26 246.03
2 701.41 540.81 244.14 386.80 162.19 431.35 176.74 174.40
8 316.66 875.26 196.36 440.87 186.54 229.05 299.67 88.89
24 92.67 790.25 313.36 557.33 263.57 82.75 441.21 42.59
48 2.65 534.73 393.32 216.96 322.28 50.10 642.95 16.04
72 2.88 336.54 322.01 522.57 331.05 40.04 531.83 10.75
120 0.74 278.65 237.90 414.03 109.73 17.70 283.96 7.15
168 0.73 188.86 204.72 423.70 97.28 16.95 274.63 3.25
240 0.48 134.33 185.87 398.62 120.64 13.67 202.64 2.92
336 0.47 31.22 145.98 243.38 88.72 7.15 193.85 1.61

LLOQ, 0.244 µg equiv/g tissue.