TABLE 2.
Pharmacokinetic parameters total radioactivity concentration-time data ([14C]CA102N and metabolites) following a single intravenous administration of a nominal 200 mg/kg of [14C]CA102N in group 2 tumor-bearing female BALB/c athymic (nu+/nu+) mice.
| Parameter | Unit | Value |
|---|---|---|
| Lambda_z | 1/h | 0.03 |
| t1/2 | h | 22.4 |
| Tmax | h | 0.5 |
| Cmax | μg equiv/ml | 1798.5 |
| C0 | μg equiv/ml | 1985.6 |
| Clast_obs/Cmax | 5.5E-05 | |
| AUC 0-t | μg equiv/ml*h | 18329.2 |
| AUC 0-inf_obs | μg equiv/ml*h | 18332.4 |
| AUC 0-t/0-inf_obs | 0.99 | |
| AUMC 0-inf_obs | μg equiv/ml*h^2 | 161062.0 |
| MRT 0-inf_obs | h | 8.7 |
| Vz_obs | (mg)/(μg equiv/ml) | 0.3 |
| Cl_obs | (mg)/(μg equiv/ml)/h | 0.01 |
| Vss_obs | (mg)/(μg/mL) | 0.09 |
Mean dose administered: 197.27, SD, 13.18. N = 5 for all groups, except where noted; BQL, below the lower limit of quantitation; ND, not determined; SD, Standard Deviation. Abbreviations: AUC, the area under the concentration-time curve; Cmax, maximum concentration; t½, elimination half-life; Tmax, time to reach Cmax.