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. 2024 Dec 18;15(12):913. doi: 10.1038/s41419-024-07297-y

Fig. 3. The expression of miR-320d is elevated in colorectal cancer tissues and colorectal cancer serum exosomes, and miR-320d can be transported to endothelial cells via exosomes.

Fig. 3

A–D Expression profile of miR-320d in CRC tissues and paracancerous tissues obtained from the GEO tissue database, and its correlation with TNM staging. E Expression level of miR-320d in CRC and HD serum exosomes from the GEO serum exosome database. F Comparison of miR-320d expression in CRC tissues and paracancerous tissues (n = 38). G Comparison of miR-320d expression in serum exosomes of HD and CRC patients (HD n = 70; CRC n = 108). H Expression of miR-320d in exosomes secreted by cells after overexpression of miR-320d in SW480 cells and subsequent incubation of exosomes with endothelial cells. I Expression of miR-320d in exosomes secreted by cells after knockdown of miR-320d in HCT-116 cells and subsequent incubation of exosomes with endothelial cells. (Two-tailed paired t-test, two-tailed unpaired t-test or Mann–Whitney test *P < 0.05, **P < 0.01, ****P < 0.0001).