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. 2024 Dec 18;15(12):913. doi: 10.1038/s41419-024-07297-y

Fig. 9. Exosomal miR-320d promotes angiogenesis in colorectal cancer by silencing GNAI1 affecting the JAK2/STAT3 signaling pathway.

Fig. 9

A, B Transwell (A) and cell wound-healing assay (B) verifying the effect of exosomal miR-320d targeting GNAI1 on HUVEC migration capacity. C In vitro angiogenesis assay confirming the effect of exosomal miR-320d targeting GNAI1 on HUVEC angiogenic capacity. D Western Blots detection of the effect of exosomal miR-320d-targeted GNAI1 on the phosphorylation of JAK2/STAT3 and VEGFA expression levels in HUVEC. E Schematic of the working model. (Two-tailed unpaired t-test or Mann–Whitney test *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).