Fig. 7. Hypothetical model of the effect of Jdp2 depletion and Gaba receptor-family and antioxidation response in the initiation of neural differentiation.

Schematic models of the pathways of Jdp2 depletion in the presence of NAC for the neural differentiation of GCPs. NAC induces xCT channels and calcium uptake, to generate antioxidation, including GSH production, thus inducing GAabra1 and 6 gene activation, which might result in the neural induction of PGCs. The original of the figure presented in Fig. S4 was by C–C. Ku et al. [10, 11], with permission to reuse and modify.