Table 4.

Vascular and bleeding complication rates with various closure methods for femoral artery access compared by sex.

Closure method	Male	Female	p‐value
Manual compression
Any 72‐h bleeding	41/2613 (1.6%)	66/1482 (4.5%)	< 0.001
Access site bleeding	9/2613 (0.3%)	25/1482 (1.7%)	< 0.001
Hematoma	7/2613 (0.3%)	32/1482 (2.2%)	< 0.001
Retroperitoneal bleed	1/2613 (0.04%)	11/1482 (0.7%)	< 0.001
Vascular complication	8/2613 (0.3%)	12/1482 (0.8%)	0.020
Any closure device
Any 72‐h bleeding	39/4903 (0.8%)	44/2444 (1.8%)	< 0.001
Access site bleeding	8/4903 (0.2%)	18/2444 (0.8%)	< 0.001
Hematoma	10/4903 (0.2%)	19/2444 (0.8%)	< 0.001
Retroperitoneal bleed	5/4903 (0.1%)	8/2444 (0.3%)	0.031
Vascular complication	9/4903 (0.2%)	5/2444 (0.2%)	0.846
Angioseal
Any 72‐h bleeding	24/2411 (1.0%)	20/1166 (1.7%)	0.071
Access site bleeding	4/2411 (0.2%)	7/1166 (0.6%)	0.028
Hematoma	4/2411 (0.2%)	8/1166 (0.7%)	0.012
Retroperitoneal bleed	3/2411 (0.1%)	4/1166 (0.3%)	0.166
Vascular complication	6/2411 (0.2%)	1/1166 (0.1%)	0.302
Suture based closure
Any 72‐h bleeding	3/1040 (0.3%)	9/424 (2.1%)	< 0.001
Access site bleeding	0/1040 (0.0%)	6/424 (1.4%)	N/A
Hematoma	0/1040 (0.0%)	2/424 (0.5%)	N/A
Retroperitoneal bleed	0/1040 (0.0%)	0/424 (0.0%)	N/A
Vascular complication	0/1040 (0.0%)	1/424 (0.2%)	N/A
Mynx
Any 72‐h bleeding	12/1452 (0.8%)	15/854 (1.8%)	0.048
Access site bleeding	4/1452 (0.3%)	5/854 (0.6%)	0.251
Hematoma	6/1452 (0.4%)	9/854 (1.1%)	0.067
Retroperitoneal bleed	2/1452 (0.1%)	4/854 (0.5%)	0.133
Vascular complication	3/1452 (0.2%)	3/854 (0.4%)	0.511