Table 6. Representative examples of a regio- and stereoselective Rh(i)-catalyzed [(2+2)+2] of 1,6-enynes containing various alkynyl and alkenyl substituent with an exogenous acrylamide.
Entry | x | R1 | R2 | Yield (%) | ee (%) |
---|---|---|---|---|---|
1 | 3 | Me | Me | >99 | >99 |
2 | 5 | " | Et | 86 | >99 |
3 | 10 | H | Ph | 47 | 94 |