Table 8. Control experiments for the regio- and stereoselective Rh(i)-catalyzed [(2+2)+2] carbocyclization reaction with 1,6-enynes with racemic allylic alcohols.
Entry | R | n | Yield (%) | ee (%) |
---|---|---|---|---|
1a | H | 1 | 60 | 98 |
2 | Me | 1 | 0 | — |
3 | H | 2 | 0 | — |
dr = (R, 5S, 7aR) : (S, 5R, 7aR) : {two unspecified diastereoisomer} = 7 : 2.5 : 1.