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. 2024 Sep 12;16(4):1490–1505. doi: 10.1039/d4sc02645d

Table 8. Control experiments for the regio- and stereoselective Rh(i)-catalyzed [(2+2)+2] carbocyclization reaction with 1,6-enynes with racemic allylic alcohols.

graphic file with name d4sc02645d-u8.jpg
Entry R n Yield (%) ee (%)
1a H 1 60 98
2 Me 1 0
3 H 2 0
a

dr = (R, 5S, 7aR) : (S, 5R, 7aR) : {two unspecified diastereoisomer} = 7 : 2.5 : 1.