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. 2024 Sep 12;16(4):1490–1505. doi: 10.1039/d4sc02645d

Table 9. Representative examples of a stereoselective Rh(i)-catalyzed [(2+2)+2] of 1,6-enynes with exogenous 1,2-disubstituted alkenes.

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Entry Z R Time (h) Yield (%) ee (%)
1 NTs H 4 58 99
2a " Me 3 12 81
3 " Ph 48 NR
4 O H 3 17 87
5 C(CO2Me)2 " 72 NR
a

The reaction condition was modified with DCE as solvent at 60 °C instead.