Table 9. Representative examples of a stereoselective Rh(i)-catalyzed [(2+2)+2] of 1,6-enynes with exogenous 1,2-disubstituted alkenes.
Entry | Z | R | Time (h) | Yield (%) | ee (%) |
---|---|---|---|---|---|
1 | NTs | H | 4 | 58 | 99 |
2a | " | Me | 3 | 12 | 81 |
3 | " | Ph | 48 | NR | — |
4 | O | H | 3 | 17 | 87 |
5 | C(CO2Me)2 | " | 72 | NR | — |
The reaction condition was modified with DCE as solvent at 60 °C instead.